MOA

THIAMINE (Vitamin B1) MOA

Combines with ATP to form thiamine pyrophosphate coenzyme, a necessary component for carbohydrate metabolism. The brain is extremely sensitive to thiamine deficiency.

TRANEXAMIC ACID (TXA, Cyklokapron) MOA

Reduces plasminogen activation, mitigating conversion to plasmin.

VASOPRESSIN (Pitressin) MOA

Vasopressin acts by direct stimulation of smooth muscle receptors. When given in extremely high doses, it acts as a noradrenergic peripheral vasoconstrictor.

VECURONIUM (Norcuron) MOA

Vecuronium is an intermediate-acting, non-depolarizing, neuromuscular blocking agent. Non-depolarizing agents produce skeletal muscle paralysis by blockade at the myoneural junction. Unlike depolarizing agents, vecuronium has little agonist activity, with no depolarizing effect at the motor endplate.

VERAPAMIL (Isoptin) MOA

Verapamil inhibits the movement of calcium ions across cell membranes. The slow calcium ion current blocked by verapamil is more important for the activity of the sinoatrial node and atrioventricular node than for many other tissues in the heart. Verapamil decreases atrial automaticity, reduces atrioventricular conduction velocity, and prolongs the atrioventricular nodal refractory period. In addition, verapamil depresses myocardial contractility, reduces vascular smooth muscle tone, and dilates coronary arteries and arterioles in normal and ischemic tissues.